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The incidence of malformations exceeded concurrent and historical controls at 0.01 mg/kg/day (kidneys, scapula), 0.01 mg/kg/day (eyes, forelimb), 0.025 mg/kg/day (brain, tail and sacral vertebrae, major blood vessels and heart, umbilicus), 0.025 mg/kg/day (sternum) and at 0.05 mg/kg/day (parietal bones, major blood vessels)

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Additionally, dysregulation of glycogen synthase kinase-3 beta (GSK-3) and reduced brain-derived neurotrophic factor (BDNF) levels further compromise neuronal survival and synaptic function 9,10,11,12

After a three-day induction phase (consisting of low-carbohydrate meals and broth), SL completed 21 consecutive days of water-only intake under close inpatient monitoring

The dual action synergistically suppresses hepatic de novo lipogenesis while promoting lipid catabolism, resulting in a net reduction of hepatic steatosis (41, 42)