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TODAY Study Group, Bjornstad P, Drews KL et al (2021) Long-term complications in youth-onset type 2 diabetes

The pivotal trials demonstrated: Between 50-100% mean IGF-1 increase a substantially more powerful GH response than traditional peptides 15% reduction in visceral adipose tissue over 26 weeks, measured by CT scan Improvements in triglycerides and metabolic markers associated with visceral fat reduction The word to remember here is intensity

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As type 2 diabetes has a multifactorial pathogenesis, there is an urgent need for differently acting pharmacological compounds at different stages of the disease

Participants had an average age of about 65 years and were followed for up to three years after initiating treatment

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