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10.1016/j.xcrm.2021.100263
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doi: 10.1016/j.metop.2022.100220
In T2DM, the inhibition of glucagon secretion in response to serum glucose levels is impaired, leading to sustained hyperglycemia due to prolonged hormone action [63]
This is the minimum timeframe established by clinical trial protocols for safe dose escalation
Lancet 398(10300):583598
