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146 The rationale for selecting the victim drugs was based on their being commonly used or a narrow therapeutic index, with different Biopharmaceutics Classification System (BCS) classifications

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This preventive effect may ultimately prove more valuable than the therapeutic one, since preventing diabetes avoids decades of associated complications

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The medication has been authorised by regulatory authorities such as the European Medicines Agency (EMA) following clinical trials demonstrating its safety and effectiveness

Both activate GLP-1 receptors, and combining them increases side effect risk, particularly nausea and vomiting, without providing additional benefit