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In launching orforglipron, Lilly will be competing with Novo Nordisk and its oral obesity drug, oral semaglutide, the same active ingredient as in its injectable obesity drug, Wegovy, and injectable Type 2 diabetes drug, Ozempic

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Patients who experience serious reactions should discontinue tirzepatide

- The increase in pancreatic mass may also be due to the possible inclusion of type 1 diabetic patients (who have decreased pancreatic mass) in the type 2 diabetic control group [163]

A semaglutide plateau is a normal observation, and stopping treatment can lead to significant weight regain

It leads to higher insulin levels, which promote fat storage , particularly around the abdomen