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GLP-1RAs and cardiovascular-renal outcomes in type 2 diabetes systematic review (2021) highlights significant reductions in cardiovascular events, kidney disease progression, and mortality among GLP-1 users

doi: 10.1016/S0140-6736(87)91194-9 22 HolstJJ

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GLP-1s will continue to disappoint unless we target the computational failure mode John Crary not only is AD (the biology) a complex multifactorial process, so is dementia the clinical syndrome

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It is a prescription metabolic medication with a mechanism of action that has nothing in common with the substances that standard panels target