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Key safety considerations include: Absolute contraindications: Personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2) [1] Important warnings and precautions: Not recommended in patients with severe gastroparesis IBS-specific assessment: Dehydration risk increases when gastrointestinal side effects occur, particularly with diarrhea or persistent nausea limiting fluid intake