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and (ii) by promoting lipid storage in adipose tissue in the periphery

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Concerns about lean mass loss and metabolism Clinical data shows semaglutide can reduce lean body mass, with losses ranging from nearly 0% to 40% of total weight reduction

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Warning signs include muscle weakness or cramps, palpitations, persistent fatigue, severe vomiting or diarrhoea, and paraesthesia

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Experimental and clinical data indicate that GLP-1RAs reduce circulating pro-inflammatory cytokines, improve endothelial function, and favour macrophage polarization toward an anti-inflammatory M2 phenotype, thereby attenuating adipose tissue inflammation

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Diabetes Spectrum : A Publication of the American Diabetes Association, 30 (3), 153-156

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Centers For Disease Control and Prevention (CDC)

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