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For example, operant responding for palatable food in rats is reduced by infusion of exendin-4 or GLP-1 into either the VTA or ACB [66,83], PVT [21], HPCv [69], lPBN [87], dorsal LS [88] and supramammillary nucleus (SuM) or LHA [86]

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Only a small percentage of patients experience it during the initial phases and after dose escalation

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Searches were conducted in May 2022 using the following databases: Embase, Ovid Medline, CINAHL, Cochrane Central Register of Controlled Trials, Web of Science: Science Citation Index Expanded, Latin American and Caribbean Health Sciences Literature (LILACS), and Google Scholar

Both formulations share an elimination half-life of about one week, remaining in circulation for around five weeks post-last dose, with clearance rates of 0.05 L/h for subcutaneous and 0.04 L/h for oral in healthy individuals [9, 13]