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Description
The NDA is based on results from REDEFINE 1, a 68-week, phase 3, randomised, double-blind, placebo-and active-controlled trial that evaluated the efficacy and safety of once-weekly, CagriSema compared to semaglutide 2.4 mg alone, cagrilintide 2.4 mg alone, or placebo, all as an adjunct to lifestyle intervention in 3,417 adults with obesity (BMI 30 kg/m2) or overweight (BMI 27 kg/m2) with one or more obesity-related complications and without diabetes, and REDEFINE 2, a double-blind, randomised, placebo-controlled, 68-week, phase 3 trial that evaluated the efficacy and safety of once-weekly CagriSema versus placebo, as an adjunct to lifestyle intervention in 1,206 adults with type 2 diabetes and either obesity (BMI 30 kg/m2) or overweight (BMI 27 kg/m2)

Heppner KM, Marks S, Holland J, Ottaway N, Smiley D, Dimarchi R, et al

[DOI] [PubMed] [Google Scholar] 175.Tan T.M., Field B.C., McCullough K.A., Troke R.C., Chambers E.S., Salem V., Gonzalez Maffe J., Baynes K.C., De Silva A., Viardot A., et al

Is it the decreased inflammation from a significant weight loss

The active ingredient in Zepbound, Tirzepatide , which is also present in the drug Mounjaro, prescribed off-label for weight loss, functions by mimicking glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)

Your prescriber will need to attest that you met the clinical criteria when you first started the medication
