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Why Do These Side Effects Happen

MarchettiPLupiRBuglianiMKirkpatrickCLSebastianiGGriecoFAet al

In individuals with T2D, epigenetic modifications, specifically increased DNA methylation of the GLP-1R gene, reduce receptor expression, impairing the function of GLP-1 and lowering insulin secretion

During embryogenesis, the heart and the GI tract develop in proximity and share common signaling pathways and structural components

In mouse models of Parkinsons disease induced by either -synuclein preformed fibrils or -synuclein overexpression, treatment with 3 mg/kg NLY01 twice weekly for 5 months protected against neurodegeneration, including -synuclein aggregation and loss of dopaminergic neurons (46)

Bodinham CL, Smith L, Thomas EL, et al