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Lastly, the systemic effects of GLP-1RAs, such as body weight loss [103] and potential reduction in muscle mass [104], pose significant challenges for elderly individuals with neurodegenerative diseases

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Tocilizumab (IL-6 Receptor Antagonist) has been shown to have efficacy slightly higher than methotrexate, but with slightly higher incidence of side effects

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[1] Current NHS availability is limited