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Conclusion GLP-1RAs show significant promise as a potential disease-modifying therapy for neurodegenerative and inflammatory eye diseases, acting through both systemic metabolic improvements and direct ocular mechanisms, representing a paradigm shift beyond their metabolic indications.

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Updated for 2026 with CMS-0057-F rule, Medicare GLP-1 Bridge program, MFN pricing deals, oral Wegovy approval, and AHIP reform pledges.
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