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SUSTAINABLE RESULTS

The gradual dose escalation schedule per the SmPC is specifically designed to improve tolerability

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2.4 Circular dichroism (CD) studies The far-UV circular dichroism (CD) spectra of the SR18 were recorded in a quartz (Helma) cell with a path length of 0.1 cm at 25 C under different solvent conditions, such as 1X PBS (phosphate buffered saline), 30 mM SDS (Sodium dodecyl sulphate), 20% TFE (2,2,2-trifluroethanol), and 20% HFIP (1,1,1,3,3,3-hexafluro-2-propanol), by using the Chirascan CD spectrometer system (Applied Photophysics)

Most patients who stop GLP-1 therapy for 2 to 4 weeks experience modest weight rebound, typically 2 to 5 pounds, though individual responses vary