semaglutide and suicide risk Postmarket safety profile of suicide/self-injury for GLP-1 receptor agonist: a real-world pharmacovigilance analysis FDA Says to Drop Suicide

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GLP-1 has an impact on various biological mechanisms, including improved insulin sensitivity, inhibition of glucagon synthesis, slowing gastric emptying [19], and reduced pancreatic cell apoptosis, when it signals through its specialized G protein-coupled receptor (GPCR), GLP-1R [20]

You cant simply replace collagen by adding it back in