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The spending increase is driven primarily by higher outpatient costs, an increase of $438 in the first year, likely reflecting monitoring visits for dose titration and managing side effects

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We design the study with the exact same strict rules as a traditional trial, like who gets included, how they are matched, and how we measure success, but we apply these rules to historical medical records, Xiong said

While some plans may cover part of the medication cost or related visits, others might classify the injections as elective or weight management services, limiting coverage

Rismanchi et al., 2025)