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Treatment with liraglutide injection 1.2 mg and 1.8 mg as add-on to glimepiride resulted in a statistically significant reduction in mean HbA 1c compared to placebo add-on to glimepiride (Table 7)

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Tirzepatide (Zepbound) has shown the highest average weight loss in trials, at up to 21%, compared to about 14 to 18% for semaglutide (depending on form and dose) and 11% for oral orforglipron

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Animals were then sorted post-hoc into 4 groups based on estrous phase, and both body weight and behavioral responses to this dose of semaglutide were compared (Fig
