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However, with the development of OX-SR, a sustained-release oxyntomodulin analogue which employs 5 central, depot-forming, amino acid substitutions between residues 16-27 of the human peptide (exact sequence not disclosed by authors), an OXM analogue capable of bringing about GCGR-mediated increases in energy expenditure was developed, and despite having an orexigenic effect actually elicited 2% weight loss following 3 days administration in rats (249)

Alternatives to Semaglutide for weight management include medications such as: Orlistat Phentermine-topiramate Naltrexone-bupropion Liraglutide In addition to their use in chronic weight management, some of these medications, like liraglutide, also serve as alternatives for managing blood sugar levels and high blood pressure