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What the Clinical Trial Showed The evidence behind the pill comes from a large clinical trial called OASIS-4

A paired Wilcoxon signed-rank test was used to compare BMI at baseline and follow-up

Resmetirom and other thyroid hormone analogs reduce hepatic TG, inflammatory factors, fibrosis markers and ALT levels and reduce hepatic steatosis lipid peroxidation (283)

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Renal or hepatic impairment does not significantly alter elimination times, and no dose adjustments are required based on kidney or liver function
