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The primary glucose-lowering effect of metformin resides in the gut, not the circulation: results from short-term pharmacokinetic and 12-week dose-ranging studies

Sample Size Calculation The hypothesized superiority of semaglutide to liraglutide for the primary and confirmatory secondary end points was assessed using a predefined hierarchical gatekeeping approach (eTable 1 in Supplement 3), 10 with a statistically superior result (2-sided at the 5% significance level) required for each end point before the next could be tested

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Incretins encourage the production of insulin from the pancreas