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When stool slows and spends more time in the colon, extra fluid helps keep it softer so it passes without additional strain
A rapid dissociation rate is also required to allow ligands to leave the receptor timeously after activation, to avoid internalization and ultimately maintain the quantity of the incretin receptors in the body

If you have diabetes and are taking sulfonylureas or insulin alongside Wegovy, be aware that your healthcare provider may need to adjust these medications to reduce the risk of hypoglycaemia (low blood sugar)

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Patients should seek urgent medical attention for severe abdominal pain, persistent vomiting, or signs of pancreatitis
