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First, novel analogues with enhanced central penetration or receptor selectivity should be prioritized

Bottom Line GLP-1 medications are useful tools, but they are not the only tools

Patients with a history of heart issues should be closely monitored, and any signs of dizziness, fainting, or irregular heart rhythms should be promptly communicated to a healthcare professional

While adjusting the medication might be the right move, you might have other options to consider first

Since the selective TRPA1 channels blockers A967079 and HC030031 fully abolished all Ca 2+ -elevating actions of JWU-A021 (Fig