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Before starting any GLP-1 medication, Service Members should work with their DoW medical officer or Primary Care Manager/Provider to ensure it is medically appropriate and to review how it might affect deployments, training, and overall readiness

Starting with a lower dose and gradually increasing it may help reduce adverse reactions

Patients with certain genetic variants may benefit from earlier morning injections if circadian-dependent GLP-1 signaling improves their appetite suppression during waking hours, while others may see equivalent results with evening administration

45 Remarkably, the recent SELECT trial proved the cardiovascular efficacy of subcutaneous semaglutide in reducing the primary cardiovascular composite endpoint (death from cardiovascular causes, non-fatal MI or non-fatal stroke) in both overweight and obese patients with established atherosclerotic CVD

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