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These benefits are thought to arise from the drugs effects on the brain, as well as their anti-inflammatory potential

Walking, strength training, or yoga can enhance results

These high costs, lower adherence in practice, and frequent weight regain after discontinuation, each highlight the importance of complementary nutritional and lifestyle counseling to help maximize overall efficacy and cost-effectiveness

On the other hand, preclinical studies in rodents have shown that co-administration of a long-acting GIPRA synergistically enhances the glucose-lowering and weight-reducing effects of GLP-1RA (75)

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5,6 A recent study on tirzepatide-related DILI proposed that elevated liver enzyme levels might result from the rapid mobilization of fat from the liver, a possible mechanism of liver injury
