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Each comorbidity represents a potential therapeutic target where GLP-1 receptor activation provides metabolic advantages beyond appetite suppression

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Remember that a 5% weight loss can show health improvements for those with obesity

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GLP-1 RAs are preferred second-line agents in patients with T2DM with established atherosclerotic cardiovascular diseases (ASCVD) in light of their demonstrated ASCVD benefit, high efficacy, low potential for hypoglycaemia and potential for weight loss

He explained that since GLP-1 drugs have raised a number of safety concerns, manufacturers are extra careful during development to avoid pushing out medications with irreversible adverse effects