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A 2021 trial published in the New England Journal of Medicine (Lundgren et al.) found that combining exercise with GLP-1 treatment led to better long-term weight maintenance than either approach alone

At present, the effects of incretin combination therapies on weight loss are approaching those of bariatric surgery, marking the advent of a new era in pharmacological treatment for obesity

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Nat Med2004 Jul;10(7):727-33

However, treatment decisions should always be individualised based on comprehensive risk assessment, existing comorbidities, and alignment with current NICE guidance for both diabetes (NG28) and cardiovascular disease management (NG238)