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The takeaway: strong human data on the anchor, solid pharmacology on the amplifier, and a genuine gap where the blend itself would need its own trial

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Interestingly, while we do not know the role of GLP-1 in this circuit on food reward several studies have explored the therapeutic potential of nigro-striatal GLP-1 action in animal models of Parkinson's disease (Harkavyi et al., 2008

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