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3 Theyre not meant for everyone

These benefits, along with already widespread use and generally good tolerability profile, have piqued interest in the potential benefit of SGLT2i and GLP1-RA in patients with rheumatologic conditions, who are at higher risk of cardiovascular and renal complications

Several large-scale cardiovascular outcome trials (including LEADER, SUSTAIN-6, and REWIND) have shown that certain GLP-1 receptor agonists liraglutide, semaglutide, and dulaglutide reduce the risk of major adverse cardiovascular events such as heart attack, stroke, and cardiovascular death in people with established cardiovascular disease or multiple cardiovascular risk factors

Protein degradation in the infant gut Even if trace amounts of a GLP-1 agonist did enter breast milk, the infant would need to absorb it orally for any systemic effect

Mario Morieri

Table 3 exhibits the regulatory effects of typical mushroom polysaccharides on gut microbiota composition in IBD and other inflammatory models
