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(B) Quantification of the number of autophagosomes

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Sample sizes were guided by prior experience with the db/db mouse model and were designed to provide 80% power ( = 0.05) to detect biologically meaningful differences in metabolic outcomes

Insulin resistance in this group of patients results from defects at the molecular level, including impaired insulin receptor-related signaling pathways enhanced by obesity and its features: Excess visceral fat, chronic inflammation, and reactive oxygen species