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Week 1-4: 1mg weekly Week 5-8: 2mg weekly Week 9-12: 4mg weekly Week 13-16: 6mg weekly Week 17-20: 8mg weekly Week 21+: 12mg weekly (if tolerated) The Phase 3 TRIUMPH-4 trial used a slightly modified approach

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Healthcare providers should proactively adjust antihypertensive regimens to prevent excessive blood pressure lowering while maintaining adequate control

But while you are taking the medication, it is important to also learn the habits and tools that will help you long-term: meal planning protein-first eating handling social situations recognizing hunger and fullness building sustainable routines The medication can create an opportunity to learn and practice those skills while appetite is quieter

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Your provider will help recommend the option that best fits your needs and health goals