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This article thoroughly traces the developmental milestones of GLP-1 drugs, from their initial discovery to their clinical application, detailing the evolution of diverse GLP-1 medications along with their distinct pharmacological properties

Eli Lilly reported another success in a study pitting its once-daily oral GLP-1 therapy Orforglipron against a competing type 2 DM therapy, this time AstraZeneca's SGLT2I Farxiga (Dapagliflozin)

MG treatment induced apoptosis of beta cells, impaired mitochondrial function, and prolonged activation of AMP-dependent protein kinase (AMPK)

In addition, perioperative management of patients on GLP-1 RAs requires careful assessment as a result of delayed gastric emptying and the associated potential risk of pulmonary aspiration

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