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Weight-loss drugs like Ozempic and Mounjaro may stop working, a phenomenon called tachyphylaxis

Weight loss drugs like semaglutide (Wegovy) and tirzepatide (Zepbound) continue to have their moment in the medical space

Last month, a patient came in for her regular cleaning

Whether adding GLP-1 to metformin provides better beta cell survival and delays disease progression remains to be validated.

As with any supplement, individuals who are pregnant, nursing, taking medications, or with medical conditions should consult a healthcare professional before use

Study: TripleHormone Receptor Agonist Retatrutide for Obesity (Phase 2 Trial, NEJM) Drug: Retatrutide a triple agonist (GLP-1, GIP, and glucagon receptors) Key Findings: Up to 28.7% mean weight loss at higher doses Marked improvements in insulin sensitivity and cardiometabolic risk factors Weight loss approaching outcomes seen with bariatric surgery, without surgery What makes Retatrutide unique is its triple-hormone mechanism, simultaneously targeting appetite regulation, energy expenditure, and glucose metabolism