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Efficacy and safety of canagliflozin as add-on therapy to a glucagon-like peptide-1 receptor agonist in Japanese patients with type 2 diabetes mellitus: a 52-week, open-label, phase IV study

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It reduces blood glucose levels and stimulates GLP-1 secretion via a G-protein mediated pathway, while also enhancing the insulin secretion through the modulation of ATP-dependent potassium channel thereby increasing calcium influx from intracellular reserves
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The Kaplan-Meier curve for the study cohort with the outcome of intestinal obstruction was shown in Fig

Ler Artigo Crook, H., & Edison, P
