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Sometimes they are not cold enough, and other times they can actually freeze items placed too close to the cooling element
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Efficacy and Safety of Tirzepatide in Type 2 Diabetes and Obesity Management (meta-analysis of SURPASS)

SURPASS Diabetes Trials SURPASS-1 through SURPASS-5 enrolled thousands of participants with type 2 diabetes, consistently demonstrating superior HbA1c reductions compared to placebo, semaglutide, and insulin glargine
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Semaglutide (Wegovy): Up to 14.9% average weight loss
