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This uncoupling is clinically relevant because it suggests the bone density changes seen in the Hansen trial are not simply a transient effect of weight loss but may reflect a direct or indirect metabolic effect of GLP-1 receptor activation on bone turnover

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The full therapeutic dose for chronic weight management is 2.4 mg weekly, reached around week seventeen for most patients

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When to Speak with Your GP or Prescriber Whilst caffeine consumption is generally safe with Saxenda, certain symptoms warrant medical review