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Lifestyle and diet also play a role in the effectiveness of these medications

Liraglutide, Sitagliptin, and Insulin Glargine Added to Metformin: The Effect on Body Weight and Intrahepatic Lipid in Patients With Type 2 Diabetes Mellitus and Nonalcoholic Fatty Liver Disease

Fasting insulin, HOMA-IR (insulin resistance index), lipid panel abnormalities, and inflammatory markers like high-sensitivity CRP provide objective evidence of metabolic disease

doi:10.7326/ANNALS-24-01590 46
Some patients notice appetite changes within the first few weeks, while weight loss typically occurs gradually over time
