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Our findings are consistent with previous studies showing additional metabolic-cardiovascular-renal benefits of combined GLP-1RA and SGLT2i use in patients with T2D 26 , and suggest a promising role for adding GLP-1RA to SGLT2i therapy in patients with MASLD

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Clinicians should consider prioritising review for people with type 2 diabetes on the affected GLP-1 RA preparation where: HbA1c greater than 86mmol/mol in the previous 3 to 6 months HbA1c greater than 86mmol/mol prior to starting the GLP1-RA HbA1c not recorded in the previous 6 months Urine albumin creatinine ratio (uACR) greater than 30mg/mmol Self-monitoring glucose readings (or Continuous Glucose Monitoring, where available) are persistently above individualised target range