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Unfortunately, many studies also reported concerns about adverse gastrointestinal events, likely related to GLP-1s role in gastric emptying

doi:10.1016/j.midw.2022.103546
Berberine appears to increase GLP-1 by: Activating bitter taste receptors (TAS2Rs) that trigger the PLC (phospholipase C) signaling pathway in L-cells, which secrete GLP-1 Feeding beneficial bacteria in the gut that then produce short-chain fatty acids (SCFAs), which stimulate L-cells to secrete GLP-1 Gut microbiome health Berberine influences the gut microbiome, Agha-Khan says

Li SC, Lindenberger U, Hommel B, Aschersleben G, Prinz W, Baltes PB

pmid:37644175 74

What is GLP-UP designed to support