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Finally, the innovative application of drug-target Mendelian randomization underscores the utility of this approach in evaluating the causal effects of pharmacological interventions on disease outcomes

Our aim is to briefly review the weight-related results reported in the context of cardiovascular outcomes trials (CVOTs) and discuss the possible implications for clinical practice

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In some studies, tirzepatide achieved up to 20% body weight reduction, while semaglutide users averaged around 15%
