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These medications carry a boxed warning about thyroid C-cell tumors in rodents, and are contraindicated in patients with personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

For individuals actively training to build muscle, requirements are substantially higher

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And because the medications work by altering appetite signals, discontinuation frequently leads to weight regain, which highlights the importance of longterm planning and supportive lifestyle changes

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