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Description
Reduces appetite aids weight loss Common Drugs (Examples) Exenatide Liraglutide Dulaglutide Semaglutide Lixisenatide Clinical Uses Type 2 Diabetes Mellitus (as monotherapy or combination) Obesity / weight management (especially semaglutide, liraglutide) Cardiovascular benefit: reduces major adverse CV events in T2DM with CVD Administration Subcutaneous injection (daily or weekly depending on formulation) Oral semaglutide available for some patients Adverse Effects Gastrointestinal: nausea, vomiting, diarrhea Risk of pancreatitis (rare but serious) Mild hypoglycemia if combined with sulfonylureas or insulin Injection site reactions Contraindications / Precautions Personal/family history of medullary thyroid carcinoma History of multiple endocrine neoplasia syndrome type 2 (MEN2) Severe gastrointestinal disease (gastroparesis) GLP-1 agonists = incretin mimetics

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By payor, prescriptions per enrollee-member increased fastest for Medicare, as volume grew three times faster than enrollment as members were using more prescriptions about 35 per enrollee in 2023

Explore how GLP-1 medications may impact fertility and menstrual cycles in women with PCOS

The field appears to be split across both modalities too: from the limited data made public in China, 13 of the 25 (52%) integrated pharma companies are using synthetic methods
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