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On the other hand, the SURPASS-5 study showed tirzepatide at doses up to 15 mg weekly reduced HbA1c by up to 2.34% and produced weight loss of up to 10.5 kg over 40 weeks, outperforming placebo by a wide margin (NCBI Bookshelf)

That said, the SELECT trial suggests the benefits of starting GLP-1 RAs begin early, even at introductory doses

Never dispose of medication in household waste or down drains, as this may contaminate water supplies

Pre-existing gastrointestinal disorders, particularly functional dyspepsia or irritable bowel syndrome, appear to predispose patients to more pronounced GI symptoms

Additionally, some medications prescribed to women may affect weightincluding depot medroxyprogesterone acetate (DMPA) contraception and certain antidepressants

PMID: 27721485 Click image to see more details HE Staining (200 magnification) and glucagon staining (400 magnification) in rat ileum