eli lilly retatrutide phase 3 trial Lilly's clinical studies investigating retatrutide, the "triple-G" agonist, have found that long-term use can achieve substantial weight loss. Read about the work via the link in the comments Retatrutide Shows 28% Weight Loss
Description
Unlike many current weight-loss drugs that focus mainly on GLP-1 activity, retatrutide targets three hormone pathways: GIP, GLP-1, and glucagon

The form of B12 in the compound matters
Fat comes back faster than muscle
On TikTok, where much of the compounded GLP-1 discussion now happens, Red Rock reviews are mixed

Claudia Fox, a doctor working on clinical trials of GLP-1s for children, told WSJ

This lipidated form remains associated with the autophagosome membranes