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GLP-1 signaling has been shown to inhibit activation of the NLRP3 inflammasome, a key driver of innate immune-mediated inflammation, and to enhance Treg activity, suggesting a broader role in restoring immune tolerance [26,27]
After 8 weeks of follow-up, the administration of lixisenatide increased the phosphorylation of NHE3, which reduced its activity in urinary extracellular vesicles in comparison to once-daily insulin glulisine treatment (Tonneijck et al., 2019)
The native peptide GLP-1-G 2 ( 1 ) showed a decreased of blood glucose concentration after 30 min, proving its efficacy in vivo, although for a short time as a rapid raise to the initial concentration level is observed after 1 h

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