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In the rat study there was an increase in nodular proliferative lesions of the liver at doses of 100 to 300 mg/kg/day (approximately 5 to 14 times the MRHD of the bupropion component in CONTRAVE on a mg/m2 basis)

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Researchers found that the participants who received tirzepatide had a significantly greater reduction in fasting glucose levels when compared to those who received semaglutide [9]

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