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Chemical characterization of leptin-activated neurons in the rat brain

Research design note: Studies investigating body composition changes should specify whether the primary endpoint is total weight, fat mass, lean mass, or waist circumference, as the compounds differ most clearly on total and adipose-specific outcomes

A large cohort study conducted in Sweden and Denmark found no statistically significant increase in suicidality associated with GLP1RA exposure

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At the start of treatment, the average age was 57.5 years, the mean BMI was 34.7 kg/m2, and 61% had type 2 diabetes

Tirzepatide is a novel glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for the treatment of type 2 diabetes mellitus and chronic weight management