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Treatment duration varies

With more than 100 publis

Currently available therapies are useful only for symptomatic control and tend to lose efficacy as time progresses

Hyperglycemia and RAAS in the Kidney High glucose levels in the proximal tubule can cause increased reabsorption of glucose, sodium and water, favored by the upregulation of SGLT2 activity and expression of Na-K-2Cl cotransporter, acquaporin-2, and urea transporters, as reported in diabetic patients (32)

Stopping the medication usually fixes the problem [26]

But like many systems in the body, it can become less reliable due to a variety of factors, including age, diet and other lifestyle habits