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The researchers optimized the potency ratio between the three receptors and used a protraction strategy that allows for once-weekly dosing, then tested the drugs in diet-induced obese mice
Presynaptic GLP-1 receptors enhance the depolarization-evoked release of glutamate and GABA in the mouse cortex and hippocampus
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A study of liraglutide identified 0.188 cases per 100 person-years (PY) versus 0.154 in patients taking MET (an SU) or pioglitazone (a TZD)
In rodents, stimulation of GLP-1 receptors in thyroid C cells promotes the secretion of calcitonin
