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Gastrointestinal adverse effects such as nausea, vomiting, ileus, and gastroparesis may be responsible for non-adherence to treatment in the long term

JAMA Intern Med (2018) 178:1098

Many users simply cannot eat enough in a six-hour window when appetite is pharmacologically blunted

This article is for informational purposes only and does not substitute for professional medical advice
Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus
"Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1)." NEJM , 387(3):205-216
