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[DOI] [PMC free article] [PubMed] [Google Scholar] 170.Jall S., Sachs S., Clemmensen C., Finan B., Neff F., DiMarchi R.D., Tschp M.H., Mller T.D., Hofmann S.M

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Oesterle TS, Ho M-F
In a mouse model of osteoarthritis induced by destabilization of the medial meniscus, glycoursodeoxycholic acid was found to mitigate disease progression, an effect associated with an increase in intestinal L cell numbers (87)

It was found that semaglutide, a long-acting GLP-1RA, could improve symptoms caused by sepsis, reduce body temperature, and decrease the bacterial load in multiple organs, along with the levels of inflammatory factors in plasma and lungs.423 These findings further confirmed the central role of the CNS in regulating the anti-inflammatory effects of GLP-1RAs, highlighting the potential application of GLP-1RAs in anti-inflammatory treatment

Researchers are also studying how these medications may shift the gut microbiome, including bacteria such as Akkermansia muciniphila
